Revealing the DNA Structural Determinants for ATM Activation
نویسندگان
چکیده
منابع مشابه
DNA structural and sequence determinants for nucleosome positioning
Positioned nucleosomes are thought to be regulators of genome function but the role of DNA sequence and structure in the control of positioning is poorly understood. We examined the intrinsic curvature of DNA sequences that are known to position histone octamers at single translational sites as a first step to investigate this problem and discovered a conserved pattern of intrinsic DNA curvatur...
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BACKGROUND In response to DNA damage, cells undergo either cell-cycle arrest or apoptosis, depending on the extent of damage and the cell's capacity for DNA repair. Cell-cycle arrest induced by double-stranded DNA breaks depends on activation of the ataxia-telangiectasia (ATM) protein kinase, which phosphorylates cell-cycle effectors such as Chk2 and p53 to inhibit cell-cycle progression. ATM i...
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The first protein structures were determined in the 1950s. In the decades that followed, development of new methods for sample preparation, crystallization, data collection, and structure analysis yielded tens of thousands of biomolecular structures. This short review highlights some of the major technical advances exemplified with selected structures.
متن کاملMyc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
BACKGROUND The MYC protein controls cellular functions such as differentiation, proliferation, and apoptosis. In response to genotoxic agents, cells overexpressing MYC undergo apoptosis. However, the MYC-regulated effectors acting upstream of the mitochondrial apoptotic pathway are still unknown. PRINCIPAL FINDINGS In this study, we demonstrate that expression of Myc is required to activate t...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.655.1